Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34208Generated: October 29, 2026

Trifluoroacetic acid → HCID 178464410, compound

https://huagongshe.com/reaction/34208

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantDiisopropylethylamineHCID 81531—
Reactanttert-butyl N-(2-(ethylamino)ethyl)carbamateHCID 13855174—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178464410HCID 178464410—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and N-(2-tert.-butyloxycarbonylamino-ethyl)-ethylamine in DMSO at ambient temperature and subsequent treatment with trifluoroacetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-7b722f2a7a154eb9969916076ca87347
Source noteuspto-grants-2008_09