Sodium Chloride → Tasimelteon

Participants

Reaction Steps

This compound was prepared similar to the above procedure using propionyl chloride and (-)-(trans)-2-(2,3-dihydrobenzofuran-4-yl)-cyclopropanemethanamine to give an oil that solidified upon standing to an off-white solid (61%, mp: 71°-72° C.). IR (NaCl Film): 3298, 1645, 1548, 1459, 1235 cm-1. [α]D25 : -17.3°; Anal. Calc'd for C15H19NO2 : C, 73.44; H, 7.87; N, 5.71; Found: C, 73.28; H, 7.68; N, 5.58.

Provenance & Evidence