Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34211Generated: October 29, 2026

Piperidin-4-ol → HCID 178463497, compound

https://huagongshe.com/reaction/34211

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidin-4-olHCID 79341—
ReactantDiisopropylethylamineHCID 81531—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178463497HCID 178463497—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 4-hydroxypiperidine in DMSO at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-4db90feb220a4f97b59a6d2398e7d6d4
Source noteuspto-grants-2008_09