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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34212Generated: October 25, 2026

Ethyl piperidine-2-carboxylate → HCID 178468882, compound

https://huagongshe.com/reaction/34212

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl piperidine-2-carboxylateHCID 27517—
ReactantDiisopropylethylamineHCID 81531—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178468882HCID 178468882—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and ethyl piperidine-2-carboxylate in DMSO at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-226744bbce004e128eeab0f8906afb00
Source noteuspto-grants-2008_09