Hydrochloric Acid → HCID 54166889, compound

Participants

Reaction Steps

1.5 g (7.6 mmol) of 2-(chloromethyl)phenylglyoxylamide were initially introduced into 200 ml of n-pentanol. Hydrogen chloride was then introduced into the mixture as a gas until it was saturated, the temperature rising to 80° C. The mixture was then stirred for a further 3 hours and concentrated, the residue was treated with water and the mixture was extracted with methyl tert-butyl ether. The combined organic phases were washed with water, dried over sodium sulfate and concentrated. After purification by column chromatography on silica gel (methyl tert-butyl ether/n-hexane), 1.1 g (54% yield) of the title compound were obtained as a colorless oil.

Provenance & Evidence