HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylallylamine → (E)-6-(4-bromo-but-2-enyloxy)-3-methyl-benzo[d]isothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylallylamine | HCID 69391 | — |
| Reactant | (1E)-1,4-dibromobut-1-ene | HCID 14316427 | — |
| Reactant | 6-Methoxy-3-methyl-benzo[d]isothiazole | HCID 67598914 | — |
| Product | (E)-6-(4-bromo-but-2-enyloxy)-3-methyl-benzo[d]isothiazole | HCID 67597941 | — |
| Product | (E)-allyl-methyl-[4-(3-methyl-benzo[d]isothiazol-6-yloxy)-but-2-enyl]-amine | HCID 67684607 | — |
| Product | 3-Methylbenzo[d]isothiazol-6-ol | HCID 135742003 | — |
Reaction Steps
from 6-methoxy-3-methyl-benzo[d]isothiazole (intermediate in Ex. 2d), after cleavage of the methoxy protecting group, reaction with (E)-1,4-dibromobutene and N-allyl-methyl-amine and salt formation, via 3-methyl-benzo[d]isothiazol-6-ol and via (E)-6-(4-bromo-but-2-enyloxy)-3-methyl-benzo[d]isothiazole there is obtained (E)-allyl-methyl-[4-(3-methyl-benzo[d]isothiazol-6-yloxy)-but-2-enyl]-amine.fumarate (1:1), MS: m/e 289 (M+H+),
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05856503 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-c1ff6e3919f443578477174d70354cff |
| Source note | uspto-grants-1999_01 |