HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,6-Dibromohexane → (RS)-1-[6-(6-bromo-hexyloxy)-benzo[d]isothiazol-3-yl]-4-methyl-pent-3-en-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,6-Dibromohexane | HCID 12368 | — |
| Reactant | N-Methylallylamine | HCID 69391 | — |
| Reactant | (RS)-3-(2-hydroxy-4-methyl-pent-3-enyl)-benzo[d]isothiazol-6-ol | HCID 136365324 | — |
| Product | (RS)-1-[6-(6-bromo-hexyloxy)-benzo[d]isothiazol-3-yl]-4-methyl-pent-3-en-2-ol | HCID 67596757 | — |
| Product | (RS)-1-[6-[6-(allyl-methyl-amino)-hexyloxy]-benzo[d]isothiazol-3-yl]-4-methyl-pent-3-en-2-ol | HCID 67684422 | — |
Reaction Steps
From (RS)-3-(2-hydroxy-4-methyl-pent-3-enyl)-benzo[d]isothiazol-6-ol (Ex. 7b) with 1,6-dibromohexane and N-allyl-methyl-amine and salt formation (analogously to Ex. 1d) via (RS)-1-[6-(6-bromo-hexyloxy)-benzo[d]isothiazol-3-yl]-4-methyl-pent-3-en-2-ol there is obtained (RS)-1-[6-[6-(allyl-methyl-amino)-hexyloxy]-benzo[d]isothiazol-3-yl]-4-methyl-pent-3-en-2-ol.fumarate (1:1), MS: m/e 403 (M+H+),
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05856503 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-a538a8c006a1445bb76f58e20c998a72 |
| Source note | uspto-grants-1999_01 |