Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 1-(4-Bromo-phenyl)-isoquinolin-6-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 1-(4-Bromo-phenyl)-6-methoxy-isoquinoline | HCID 11141535 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Hydrogen Bromide | HCID 260 | — |
| 생성물 | 1-(4-Bromo-phenyl)-isoquinolin-6-ol | HCID 136128669 | — |
반응 단계
The 1-(4-bromo-phenyl)-6-methoxy-isoquinoline obtained is boiled under reflux in 53 ml of acetic acid and 37 ml of 62% aqueous hydrobromic acid. Subsequently, after cooling to room temperature and addition of 150 ml of ethyl acetate the separated precipitate is filtered off. The crystals are washed with ethyl acetate and dried. There are obtained 7.6 g of 1-(4-bromo-phenyl)-isoquinolin-6-ol, MS: m/e 300 (M+H+, 1 Br).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05856503 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-86d1d6104c494dc4936bdd7625021dfe |
| 출처 메모 | uspto-grants-1999_01 |