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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34222Generated: October 29, 2026

Diisopropylethylamine → HCID 178463453, compound

https://huagongshe.com/reaction/34222

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
ReactantHCID 178420865HCID 178420865—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178463453HCID 178463453—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine in DMSO at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-dc59ee25df1d45cab69d2b1375be2719
Source noteuspto-grants-2008_09