Formamide → HCID 10994090, compound

Participants

Reaction Steps

A solution of 230 mg of [2-amino-4-[6-(allyl-methyl-amino)-hexyloxy]-phenyl]-(4-bromo-phenyl)-methanone in 0.5 ml of formic acid and 2 ml of formamide is boiled at 165° C. for 25 min., then concentrated and converted into the free amine (title compound) with methylene chloride/saturated sodium bicarbonate solution. After purification (silica gel, methylene chloride/methanol 2.5% to 10%) the residue is dissolved in methylene chloride/ether and treated with 23.7 mg of fumaric acid. After stirring and filtration there are obtained 30 mg of allyl-[6-[4-(4-bromo-phenyl)-quinazolin-7-yloxy]-hexyl]-methyl-amine.fumarate (1:1), m.p 90°-95° C., MS: m/e 454 (M+H+, 1 Br).

Provenance & Evidence