Formamide → HCID 178457214, compound

Participants

Reaction Steps

A solution of 445 mg of [2-amino-4-[6-(allyl-methyl-amino)-hexyloxy]-phenyl]-(4-bromo-phenyl)-methanone in 1 ml of formic acid and 4 ml of formamide is boiled at 160° C. for 35 hrs., then concentrated and converted into the free amine (title compound) with sodium bicarbonate solution saturated with methylene chloride. The residue is dissolved in methylene chloride/ether and treated with 73 mg of fumaric acid. After stirring the mixture is decanted and the residue is triturated with ether and filtered off. There are obtained 30 mg of (RS)-allyl-[6-[4-(4-bromo-phenyl)-3,4-dihydro-quinazolin-7-yloxy]-hexyl]-methyl-amine.fumarate (1:1), m.p 120° C. (decomposition), MS: m/e 456 (M+H+, 1 Br).

Provenance & Evidence