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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34223Generated: November 2, 2026

1,2,3,6-Tetrahydropyridine → HCID 178463468, compound

https://huagongshe.com/reaction/34223

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2,3,6-TetrahydropyridineHCID 12750—
ReactantDiisopropylethylamineHCID 81531—
ReactantPentafluorphenol-tetramethyluronium hexafluorophosphatHCID 15840204—
Reactant6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazolineHCID 178463504—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178463468HCID 178463468—

Reaction Steps

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 1,2,3,6-tetrahydropyridine in DMSO at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-2c59be52106b4a93accd19d5c6e61534
Source noteuspto-grants-2008_09