Cyclopropylamine → HCID 53714022, compound

Participants

Reaction Steps

A solution of 9.3 g of monomethyl (1RS,2RS)-1,2-cyclopropanedicarboxylate, 4.0 ml of N-cyclopropylamine and 11.6 g of N(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride in 210 ml of methylene chloride is treated at 0° C. with 0.7 g of dimethylaminopyridine and subsequently stirred at room temperature for 2 hrs. The reaction solution is worked-up with methylene chloride/10% potassium hydrogen sulphate solution. The organic phase is washed with saturated sodium bicarbonate solution, dried and concentrated to give 10.6 g of methyl (1RS,2RS)-2-cyclopropylcarbamoyl-cyclopropanecarboxylate.

Provenance & Evidence