Hydroquinone → HCID 13219901, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 48 mg of (3S, 4R)-4-([2-(p-nitrobenzyloxycarbonylamino)ethylthio]carbonylmethyl)-3-[(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl]-1-[1-(p-nitrobenzyloxycarbonyl)-1-triisopropoxyphosphoranylidenemethyl]-2-azetidinone and 30 mg of hydroquinone in 5 ml of xylene was heated at 120° C. under a stream of a nitrogen gas for 13 hours. The xylene was then distilled off and the residue was subjected to chromatography using a Lobar column A eluted with a 2:1 by volume mixture of chloroform and ethyl acetate, to give crude crystals, which were recrystallized from a mixture of benzene and ethyl acetate, affording 19 mg (yield 51%) of colourless prisms, melting at 148°-150° C.

Provenance & Evidence