HRID342307

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：Cc1nc2c([nH]1)-c1ccccc1N(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)CC2

HCID178418305

未命名化合物

PRODUCTS

生成物

结构：Cc1nc2c([nH]1)-c1ccccc1N(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)CC2.Cl

HCID178418232

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

4'-[(2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]-2-phenylbenzanilide was dissolved in 5 ml of ethyl alcohol, the resulting solution was mixed with 0.19 ml of 4N hydrochloric acid-ethyl acetate and cooled on an ice bath and then the thus precipitated crystals were collected by filtration and washed with a small volume of ethyl alcohol to obtain 220 mg of 4'-[(2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepin-6-yl)carbonyl]-2-phenylbenzanilide hydrochloride (Example 18(2)).

WORKUP

后处理

temperaturecooled on an ice bath
filtrationthe thus precipitated crystals were collected by filtration
washwashed with a small volume of ethyl alcohol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aafe692e40c64b08a5ad7bb09bbc29cc
来源数据集: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05856564
来源说明: uspto-grants-1999_01

反应 SMILES

[CH3:1][C:2]1[NH:3][C:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[N:8]([C:15]([C:17]3[CH:37]=[CH:36][C:20]([NH:21][C:22](=[O:35])[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:19][CH:18]=3)=[O:16])[CH2:7][CH2:6][C:5]=2[N:38]=1.[ClH:39].C(OCC)(=O)C>C(O)C>[ClH:39].[CH3:1][C:2]1[NH:3][C:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[N:8]([C:15]([C:17]3[CH:37]=[CH:36][C:20]([NH:21][C:22](=[O:35])[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)=[CH:19][CH:18]=3)=[O:16])[CH2:7][CH2:6][C:5]=2[N:38]=1