HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 6-chloro-4-[(1R/S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-{(2R/S)-2-[(N-methyl-N-(pyridin-2-ylmethyl)-amino)-methyl]-piperidin-1-yl-carbonyl}-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Pentafluorphenol-tetramethyluronium hexafluorophosphat | HCID 15840204 | — |
| Reactant | n-Methyl-n-(piperidin-2-ylmethyl)-pyridin-2-ylmethyl-amine | HCID 43565105 | — |
| Reactant | 6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline | HCID 178463504 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-chloro-4-[(1R/S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-{(2R/S)-2-[(N-methyl-N-(pyridin-2-ylmethyl)-amino)-methyl]-piperidin-1-yl-carbonyl}-quinazoline | HCID 178463475 | — |
Reaction Steps
Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and N-methyl-N-(piperidin-2-ylmethyl)-pyridin-2-ylmethyl-amine in DMSO at ambient temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429597B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-84b8fcb9f8774384aaefe1cbdcc08b44 |
| Source note | uspto-grants-2008_09 |