反应详情

8.0 g of 4-n-pentylcyclohexylmethanol was dissolved in a mixture solvent of 8 ml of pyridine and 8 ml of toluene. To the solution, 6.0 g of methanesulfonyl chloride was added dropwise below 10° C., followed by stirring overnight at room temperature. After the reaction, the reaction mixture was poured into cold water and subjected to extraction with toluene, followed by washing successively with 5%-hydrochloric acid aqueous solution and water and drying with anhydrous magnesium sulfate. The resultant organic layer was subjected to filtration, followed by distilling-off of the solvent to obtain 11.3 g of 4-n-pentylcyclohexylmethyl methanesulfonate.

1. customAfter the reaction
2. extractionsubjected to extraction with toluene
3. washby washing successively with 5%-hydrochloric acid aqueous solution and water
4. dry with materialdrying with anhydrous magnesium sulfate
5. filtrationThe resultant organic layer was subjected to filtration