Hydrochloric Acid → HCID 178439114, compound

Participants

Reaction Steps

Under cooled condition with ice, 1.6 g of lithium aluminum hydride was added little by little to 100 ml of THF and stirred. A liquid mixture of 16.2 g of the 4-(2-(trans-4-(4-n-propylphenyl)cyclohexyl)ethyl)ethylbenzoate mentioned above in 200 ml of THF was added dropwise thereto. It was stirred as it was cooled with ice for 2 hours, and then 200 ml of ethyl acetate was added dropwise thereto. The reaction solution was added to 200 ml of dilute hydrochloric acid cooled with ice and extracted with 200 ml of ethyl acetate. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain 10.1 g of 4-(2-(trans-4-(4-n-propylphenyl)cyclohexyl)ethyl)benzyl alcohol.

Provenance & Evidence