Acetic Anhydride → HCID 70198796, compound

HRID 342430Notes

Reaction equation

HRID 342430 reaction equation
[C:1]([C:4]1[C:5]2[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[C:6]=2[O:7][C:8]=1[CH3:9])(=[O:3])[CH3:2].[C:15](OC(=O)C)(=[O:17])[CH3:16]>ClCCl>[C:1]([C:4]1[C:5]2[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][C:15](=[O:17])[CH3:16])[C:6]=2[O:7][C:8]=1[CH3:9])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 33677157HCID 33677157, compound

Product 1

HCID 70198796HCID 70198796, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-acetyl-7-amino-2-methylbenzo[b]furan (2.4 g) in dichloromethane (30 ml) was added acetic anhydride (1.6 g) dropwise. The solution was stirred at ambient temperature for 1 hour and evaporated in vacuo. Toluene was added to the residue and the solution was evaporated in vacuo. The residue was crystallized from diethyl ether to give 3-acetyl-7-acetylamino-2-methylbenzo[b]furan (2.92 g).

Workup

  1. customevaporated in vacuo
  2. additionToluene was added to the residue
  3. customthe solution was evaporated in vacuo
  4. customThe residue was crystallized from diethyl ether

Sources & evidence

ORD record
ord-97ae828f1eb54b52ba44567e860eb751
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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