反应详情

3-Hydroxymethyl-2-methyl-7-nitrobenzo[b]furan (1.0 g) was added to thionyl chloride (1.8 ml) with ice cooling. The mixture was stirred at ambient temperature for 30 minutes and concentrated in vacuo. To the residue was added toluene and the mixture was concentrated again. The residue was crystallized from a mixture of diethyl ether and n-hexane to give 3-chloromethyl-2-methyl-7-nitrobenzo[b]furan (1.01 g).

1. concentrationconcentrated in vacuo
2. additionTo the residue was added toluene
3. concentrationthe mixture was concentrated again
4. customThe residue was crystallized from a mixture of diethyl ether and n-hexane