反应详情

温度

100 °C

A mixture of 3-chloromethyl-2-methyl-7-nitrobenzo[b]furan (226 mg) and triethyl phosphite (0.52 ml) was stirred at 100° C. for 6 hours. The reaction mixture was cooled and concentrated in vacuo and to the residue was added toluene. The mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel. The obtained oil was crystallized from diisopropyl ether to give 3-(diethoxyphosphorylmethyl)-2-methyl-7-nitrobenzo[b]furan (93 mg).

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated in vacuo and to the residue
3. additionwas added toluene
4. concentrationThe mixture was concentrated in vacuo
5. customthe residue was purified by column chromatography on silica gel
6. customThe obtained oil was crystallized from diisopropyl ether