Sodium Hydroxide → HCID 70200213, compound

HRID 342445Notes

Reaction equation

HRID 342445 reaction equation
C([NH:4][C:5]1[C:10]2[O:11][C:12]([CH3:18])=[C:13]([C:14]([OH:17])([CH3:16])[CH3:15])[C:9]=2[CH:8]=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>C(O)C.O>[NH2:4][C:5]1[C:10]2[O:11][C:12]([CH3:18])=[C:13]([C:14]([OH:17])([CH3:15])[CH3:16])[C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 70200005HCID 70200005, compound

Product 1

HCID 70200213HCID 70200213, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A suspension of 7-acetylamino-3-(1-hydroxy-1-methylethyl)-2-methylbenzo[b]furan (1.82 g) in a mixture of ethanol (15 ml) and 3N-aqueous sodium hydroxide (10 ml) was refluxed for 20 hours. The reaction mixture was cooled, diluted with water (20 ml) and evaporated in vacuo until the ethanol of the solution was removed. The separated solid was collected, washed with water and dried to give 7-amino-3-(1-hydroxy-1-methylethyl)-2-methylbenzo[b]furan (1.42 g).

Workup

  1. temperaturewas refluxed for 20 hours
  2. temperatureThe reaction mixture was cooled
  3. customevaporated in vacuo until the ethanol of the solution
  4. customwas removed
  5. customThe separated solid was collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-22885b67b8c544d3aaf37ad5e9b3a6c0
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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