Water → HCID 70200561, compound

HRID 342459Notes

Reaction equation

HRID 342459 reaction equation
Cl.[NH2:2][C:3]1[CH:13]=[C:12]([NH:14][C:15](=[O:24])[C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])[C:6]2[O:7][C:8]([CH3:11])=[C:9]([CH3:10])[C:5]=2[CH:4]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26].O>C(O)(=O)C>[C:25]([NH:2][C:3]1[CH:13]=[C:12]([NH:14][C:15](=[O:24])[C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])[C:6]2[O:7][C:8]([CH3:11])=[C:9]([CH3:10])[C:5]=2[CH:4]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 70200669HCID 70200669, compound

Product 1

HCID 70200561HCID 70200561, compoundYield 82.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-amino-7-(2,6-dichlorobenzoylamino)-2,3-dimethylbenzo[b]furan hydrochloride (116 mg) and acetic anhydride (74 mg) in acetic acid (1 ml) was stirred at 80° C. for 1.5 hours. The reaction mixture was cooled and to the mixture was added water. The separated solid was collected, washed with water and dried to give 5-acetylamino-7-(2,6-dichlorobenzoylamino)-2,3-dimethylbenzo[b]furan (97 mg).

Workup

  1. temperatureThe reaction mixture was cooled and to the mixture
  2. customThe separated solid was collected
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7e32216914484accab3f14fe784b95ec
Source dataset
uspto-grants-1999_01
Patent number
US05858995

Reaction notes

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