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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34247Generated: October 25, 2026

Trifluoroacetic acid → HCID 178520669, compound

https://huagongshe.com/reaction/34247

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
ReactantN1-(pyridin-4-yl)ethane-1,2-diamineHCID 14834209—
Reactant6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazolineHCID 68938489—
SolventAcetonitrile tetrahydrofuranHCID 22177404—
ProductHCID 178520669HCID 178520669—

Reaction Steps

Prepared analogously to Example 61 from 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and 2-(pyridin-4-yl-amino)-ethylamine with TBTU in acetonitrile/tetrahydrofuran and subsequent reaction with trifluoroacetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07429597B2
Source datasetuspto-grants-2008_09
ORD IDord-048ad748e626414dbcd103534ddb9713
Source noteuspto-grants-2008_09