Pyridine → HCID 15308300, compound

HRID 342491Notes

Reaction equation

HRID 342491 reaction equation
[NH2:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:12](=[O:13])[CH2:11][CH2:10][C:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=3)=[N:8]2)=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:32](Cl)(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[N:35][CH:34]=1>ClCCl>[C:32]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:12](=[O:13])[CH2:11][CH2:10][C:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=3)=[N:8]2)=[CH:24][CH:25]=1)(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[N:35][CH:34]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 82604Nicotinoyl chlorideHCID 15308303HCID 15308303, compound

Product 1

HCID 15308300HCID 15308300, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3.4 g of 2-(4-aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 184°, and 0.75 ml of pyridine in 100 ml of dichloromethane is treated with 1.4 g of nicotinoyl chloride and subsequently stirred for 1 hour. The solvent is removed and the mixture is worked up in the customary manner. After recrystallization, 2-(4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one is obtained.

Workup

  1. customThe solvent is removed
  2. customAfter recrystallization

Sources & evidence

ORD record
ord-76c720c9490b4b488b7e24c5d48a7c76
Source dataset
uspto-grants-1999_01
Patent number
US05859008

Reaction notes

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