HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloropyridine → HCID 57081329, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloropyridine | HCID 12288 | — |
| Reactant | 4-Methoxybenzaldehyde | HCID 31244 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 57081329 | HCID 57081329 | — |
Reaction Steps
4-Chloropyridine is treated sequentially with LDA (1.1 molar equivalents) and 4-methoxybenzaldehyde (1 molar equivalent). The resulting carbinol is isolated and deoxygenated with triethylsilane (10 molar equivalents) and 50% trifluoroacetic acid in methylene chloride to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859015 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-80b359fd0b3e46439649448628deaec6 |
| Source note | uspto-grants-1999_01 |