Formaldehyde → 3-Benzyl-3-azabicyclo[3.3.1]nonan-9-one

Temperature

80 °C

A mixture of benzylamine(17.25 ml, 0.683 mol), acetic acid(182 ml), c-HCl (13.25 ml), cyclohexanone (13.25 ml, 0.127 mol), and aqueous formaldehyde solution (4.1M, 31.25 ml, 1.25 mol) was stirred at 80° C. for 2 h, cooled, and concentrated. The residue was partitioned between ether and water, and the pH was adjusted to 8 with solid Na2CO3. The reaction mixture was extracted with dichloromethane and the extract was dried over Na2SO4 and concentrated. This residue was taken up in 37 ml ethanol and treated with acetic anhydride (12.5 ml, 0.530 mol), stirred at room temperature for 2 h, treated with c-HCl (15 ml), and stirred at room temperature for 2 h. The reaction mixture was concentrated, and the residue taken up in water and washed with dichloromethane. The aqueous layer was adjusted to pH 8 with solid Na2CO3 and extracted with dichloromethane and ethyl acetate. The extracts combined was dried over Na2SO4 and concentrated. The residue was chromatographed on silica gel using hexane/ethyl acetate: 10/1 as eluent to afford an oil which solidified on standing, mp 48°-50.5° C., 2.4 g (20.5%).

1. temperaturecooled
2. concentrationconcentrated
3. customThe residue was partitioned between ether and water
4. extractionThe reaction mixture was extracted with dichloromethane
5. dry with materialthe extract was dried over Na2SO4
6. concentrationconcentrated
7. stirringstirred at room temperature for 2 h
8. stirringstirred at room temperature for 2 h
9. concentrationThe reaction mixture was concentrated
10. washwashed with dichloromethane
11. extractionextracted with dichloromethane and ethyl acetate
12. dry with materialThe extracts combined was dried over Na2SO4
13. concentrationconcentrated
14. customThe residue was chromatographed on silica gel
15. custom10/1 as eluent to afford an oil which

ORD record

ord-ab3c2e842b3f4b5780d5cf35460e7d58

Source dataset

uspto-grants-1999_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05859011