HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzyloxycarbonyl-3-dimethylaminopropylpiperazine → 1-[3-(Dimethylamino)propyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzyloxycarbonyl-3-dimethylaminopropylpiperazine | HCID 54155596 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[3-(Dimethylamino)propyl]piperazine | HCID 2736234 | 97.6% |
Reaction Steps
A mixture of 4-benzyloxycarbonyl-3-dimethylaminopropylpiperazine (2.21 g, 7.2 mmol), 5% Pd/C (0.36 g) in methanol (20 ml) was stirred under hydrogen atmosphere at room temperature for 38 h. After removal of catalyst by Celite filtration, the filtrate was concentrated to afford 1.20 g (97.6%) of orange color viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859011 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-34838c0e87474c00b0147ee715122c4f |
| Source note | uspto-grants-1999_01 |