反应详情

温度

5 °C

A mixture of-sodium methoxide (0.343 g, 14.9 mmol), benzylurea (1.6 g, 10.6 mmol), diethyl dimethylmalonate (1.9 g, 10 mmol) and methanol (15 mL) was heated 6 hours at reflux. The reaction mixture was concentrated and the residue was stirred with water (30 mL) at 5° C. and then hydrochloric acid was added. The solids were collected, washed with water and dried to give 1-benzyl-5,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione, m.p 136°-137° C.

1. temperaturewas heated 6 hours
2. temperatureat reflux
3. concentrationThe reaction mixture was concentrated
4. additionhydrochloric acid was added
5. customThe solids were collected
6. washwashed with water
7. customdried