Sodium Hydroxide → HCID 49842220, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(2-pyrrol-1-ylphenyl)piperazine-1-carbaldehyde (1.12 g, 4.4 mmol), sodium hydroxide (440 mg, 11 mmoL) and methanol (10 mL) was heated 14 hours at 50° C. The reaction mixture was allowed to cool to approximately 25° C. and then partitioned between water (20 mL) and dichloroethane (30 mL). The aqueous layer was separated and extracted with dichloroethane (3×30 mL). The combined dichloroethane was washed with brine and dried (K2CO3). The residue was purified by column chromatography on silica gel eluting with a gradient of 1 to 5% methanol/0.1% triethylamine/dichloroethane to give 1-(2-pyrrol-1-ylphenyl)piperazine (0.77 g, 3.4 mmol).

Provenance & Evidence