1-(4-Fluoro-2-methoxyphenyl)piperazine → 3-benzyl-1-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 342564Notes

Reaction equation

HRID 342564 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[Cl:16][CH2:17][CH2:18][CH2:19][N:20]1[CH:25]=[C:24]([CH3:26])[C:23](=[O:27])[N:22]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:21]1=[O:35]>>[ClH:16].[CH2:28]([N:22]1[C:23](=[O:27])[C:24]([CH3:26])=[CH:25][N:20]([CH2:19][CH2:18][CH2:17][N:11]2[CH2:10][CH2:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[O:14][CH3:15])[CH2:13][CH2:12]2)[C:21]1=[O:35])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 104886541-(4-Fluoro-2-methoxyphenyl)piperazineHCID 158406671-(3-chloropropyl)-3-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 702022023-benzyl-1-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride

Procedure

substituting 1-(4-fluoro-2-methoxyphenyl)piperazine and 1-(3-chloropropyl)-3-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione gave 3-benzyl-1-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 210°-212° C.; Anal.: Calcd. for C26H31FN4O3.(HCl)2 : C, 57.88; H, 6.16; N, 10.38%; Found: C, 57.50; H, 6.18; N, 10.62%;

Sources & evidence

ORD record
ord-e46d39b687184e6b8204fda610d5c654
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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