HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → 1-cyclohexylmethyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine | HCID 10491565 | — |
| Reactant | 3-(3-chloropropyl)-1-cyclohexylmethyl-5-methyl-2,4(1H,3H)-pyrimidinedione | HCID 54425154 | — |
| Product | 1-cyclohexylmethyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 70201189 | — |
Reaction Steps
substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-1-cyclohexylmethyl-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-cyclohexylmethyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 130°-132° C.; Anal.: Calcd. for C27H37F3N4O3.HCl: C, 57.99; H, 6.88; N, 10.02%; Found: C, 58.01; H, 6.80; N, 9.87%;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859014 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-33d5379ab75147c79fabf48e007ebb04 |
| Source note | uspto-grants-1999_01 |