1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70198218, compound

HRID 342570Notes

Reaction equation

HRID 342570 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH2:19]([N:26]1[CH:31]=[C:30]([CH2:32][CH2:33][CH3:34])[C:29](=[O:35])[N:28]([CH2:36][CH2:37][CH2:38][Cl:39])[C:27]1=[O:40])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[ClH:39].[CH2:19]([N:26]1[CH:31]=[C:30]([CH2:32][CH2:33][CH3:34])[C:29](=[O:35])[N:28]([CH2:36][CH2:37][CH2:38][N:14]2[CH2:15][CH2:16][N:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[O:4][CH2:3][C:2]([F:1])([F:17])[F:18])[CH2:12][CH2:13]2)[C:27]1=[O:40])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 53759888HCID 53759888, compound

Product 1

HCID 70198218HCID 70198218, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-benzyl-3-(3-chloropropyl)-5-propyl-2,4(1H,3H)-pyrimidinedione gave 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-propyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 178° C.; Anal.: Calcd. for C29H35F3N4O3.HCl: C, 59.03; H, 6.32; N, 9.49%; Found: C, 59.08; H, 6.26; N, 9.52%;

Sources & evidence

ORD record
ord-740fb0c6848c44e695b753b7933963b8
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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