HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Fluoro-2-methoxyphenyl)piperazine → 1-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Fluoro-2-methoxyphenyl)piperazine | HCID 10488654 | — |
| Reactant | 1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione | HCID 12091375 | — |
| Product | 1-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 70201818 | — |
Reaction Steps
substituting 1-(4-fluoro-2-methoxyphenyl)piperazine and 1-(3-chloropropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-{3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 196°-197° C.; Anal.: Calcd. for C19H25FN4O3.(HCl)2 : C, 49.79; H, 6.16; N, 12.22%; Found: C, 50.13; H, 6.37; N, 12.27%;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859014 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-7b65ec0322144a34bdd3c6bf45b464e9 |
| Source note | uspto-grants-1999_01 |