1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70202072, compound

HRID 342581Notes

Reaction equation

HRID 342581 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[Cl:19][CH2:20][CH2:21][CH2:22][N:23]1[C:28]([CH3:29])=[CH:27][C:26](=[O:30])[NH:25][C:24]1=[O:31]>>[ClH:19].[F:18][C:2]([F:1])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:20][CH2:21][CH2:22][N:23]2[C:28]([CH3:29])=[CH:27][C:26](=[O:30])[NH:25][C:24]2=[O:31])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 53669054HCID 53669054, compound

Product 1

HCID 70202072HCID 70202072, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-(3-chloropropyl)-6-methyl-2,4(1H,3H)-pyrimidinedione gave 1-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-6-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 217°-219° C.; Anal.: Calcd. for C20H25F3N4O3.(HCl)2 : C, 48.10; H, 5.44; N, 11.22%; Found: C, 47.96; H, 5.46; N, 11.15%;

Sources & evidence

ORD record
ord-8d3fde8759d34f38b6919741659e1995
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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