1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine → HCID 70202601, compound

HRID 342584Notes

Reaction equation

HRID 342584 reaction equation
[F:1][C:2]([F:18])([F:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.CS(O[CH2:24][C:25]1([CH2:28][N:29]2[C:34](=[O:35])[C:33]([CH3:36])=[CH:32][N:31]([CH2:37][C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:30]2=[O:44])[CH2:27][CH2:26]1)(=O)=O>>[CH2:37]([N:31]1[CH:32]=[C:33]([CH3:36])[C:34](=[O:35])[N:29]([CH2:28][C:25]2([CH2:24][N:14]3[CH2:15][CH2:16][N:11]([C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=4[O:4][CH2:3][C:2]([F:1])([F:17])[F:18])[CH2:12][CH2:13]3)[CH2:27][CH2:26]2)[C:30]1=[O:44])[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

3

Reactant 2

HCID 104915651-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazineHCID 54383660HCID 54383660, compound

Product 1

HCID 70202601HCID 70202601, compound

Procedure

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)cycloprop-1-ylmethyl methanesulfonate gave 1-benzyl-3-(1-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-ylmethyl}cycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione as an oil;

Sources & evidence

ORD record
ord-30bd4e69768e4c21a9f3ce0eee0b5269
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

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