反应详情

substituting 1-[2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-1-(4-fluorophenyl)-5-methyl-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-1-(4-fluorophenyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 166°-168° C.; Anal.: Calcd. for C26H28F4N4O3HCl.(C4H10O)0.3 ; C, 56.34; H, 5.56; N, 9.66%; Found: C, 56.06; H, 5.76; N, 9.36%;