HRID342590

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10958012

未命名化合物

结构：C[Si](C)(C)CCOCn1cc(CO)c(=O)n(CCCCl)c1=O

HCID70198195

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCOCn1cc(CO)c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O

HCID70198253

未命名化合物

PROCEDURE

实验过程

substituting 1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine and 3-(3-chloropropyl)-5-hydroxymethyl-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione gave 3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5-hydroxymethyl-1-[2-(trimethylsilyl)ethoxymethyl]-2,4(1H,3H)-pyrimidinedione;

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-868f82b0197a4159b34d41fd5e4e007d
来源数据集: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05859014
来源说明: uspto-grants-1999_01

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[C:4]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[CH:3]=1.Cl[CH2:21][CH2:22][CH2:23][N:24]1[C:29](=[O:30])[C:28]([CH2:31][OH:32])=[CH:27][N:26]([CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:40])([CH3:39])[CH3:38])[C:25]1=[O:41]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:21][CH2:22][CH2:23][N:24]3[C:29](=[O:30])[C:28]([CH2:31][OH:32])=[CH:27][N:26]([CH2:33][O:34][CH2:35][CH2:36][Si:37]([CH3:38])([CH3:40])[CH3:39])[C:25]3=[O:41])[CH2:10][CH2:9]2)=[C:4]([O:14][CH2:15][C:16]([F:18])([F:17])[F:19])[CH:3]=1