Methanol → 3-(Benzyloxy)-2,2-dimethylpropanoic acid

A mixture of 3-benzyloxy-2,2-dimethylpropanenitrile (2.5 g, 13.2 mmol), 10% aqueous sodium hydroxide (10 mL) and methanol (150 mL) was heated 8 hours at reflux and then concentrated. The residue was dissolved in water (30 mL) and the solution was washed with dichloromethane (2×10 mL), treated with 10% hydrochloric acid and extracted with ethyl acetate (4×20 mL). The combined extracts were washed with water and brine, dried (MgSO4) and concentrated to give 3-benzyloxy-2,2-dimethylpropionic acid (1.6 g, 7.5 mmol).

1. temperaturewas heated 8 hours
2. temperatureat reflux
3. concentrationconcentrated
4. dissolutionThe residue was dissolved in water (30 mL)
5. washthe solution was washed with dichloromethane (2×10 mL)
6. additiontreated with 10% hydrochloric acid
7. extractionextracted with ethyl acetate (4×20 mL)
8. washThe combined extracts were washed with water and brine
9. dry with materialdried (MgSO4)
10. concentrationconcentrated

ORD record

ord-8fa29025fb3f4853910878d3a66ac35e

Source dataset

uspto-grants-1999_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05859014