Dihydrouracil → 3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5,6-dihydro-2,4(1H,3H)-pyrimidinedione hydrochloride

Participants

Reaction Steps

substituting 1-chloro-3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane and 5,6-dihydro-2,4(1H,3H)-pyrimidinedione and recrystallizing from a solution of hydrochloric acid in alcohol gave 3-(3-{4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propyl)-5,6-dihydro-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 186°-189° C.; Anal.: Calcd. for C19H24F4N5O3.(HCl)2 : C, 44.10; H, 5.06; N, 10.83%; Found: C, 43.99; H, 5.16; N, 10.78%; and

Provenance & Evidence