HRID342604

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID237953

1-Benzyl-5-methyl-1H-pyrimidine-2,4-dione

C12H12N2O2

结构：CC(C)(CCl)CN1CCN(c2ccccc2OCC(F)(F)F)CC1

HCID70201721

未命名化合物

PRODUCTS

生成物

结构：Cc1cn(Cc2ccccc2)c(=O)n(CC(C)(C)CN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O

HCID70201499

未命名化合物

PROCEDURE

实验过程

substituting 1-chloro-2,2-dimethyl-3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propane and 1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione gave 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4839d26a1ad141cd83bb250628b02e5e
来源数据集: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05859014
来源说明: uspto-grants-1999_01

反应 SMILES

Cl[CH2:2][C:3]([CH3:24])([CH3:23])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][C:19]([F:22])([F:21])[F:20])[CH2:7][CH2:6]1.[CH2:25]([N:32]1[CH:37]=[C:36]([CH3:38])[C:35](=[O:39])[NH:34][C:33]1=[O:40])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([N:32]1[CH:37]=[C:36]([CH3:38])[C:35](=[O:39])[N:34]([CH2:2][C:3]([CH3:24])([CH3:23])[CH2:4][N:5]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[O:17][CH2:18][C:19]([F:22])([F:21])[F:20])[CH2:7][CH2:6]2)[C:33]1=[O:40])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1