1-Chloro-4-(chloromethyl)benzene → HCID 70201810, compound

HRID 342607Notes

Reaction equation

HRID 342607 reaction equation
[F:1][C:2]([F:30])([F:29])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][N:20]2[C:25](=[O:26])[C:24]([CH3:27])=[CH:23][NH:22][C:21]2=[O:28])[CH2:13][CH2:12]1.[Cl:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36]Cl)=[CH:34][CH:33]=1>>[ClH:31].[Cl:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36][N:22]2[CH:23]=[C:24]([CH3:27])[C:25](=[O:26])[N:20]([CH2:19][CH2:18][CH2:17][N:14]3[CH2:13][CH2:12][N:11]([C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=4[O:4][CH2:3][C:2]([F:29])([F:1])[F:30])[CH2:16][CH2:15]3)[C:21]2=[O:28])=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 35670025-Methyl-3-[3-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione] hydrochloride

Product 1

HCID 70201810HCID 70201810, compound

Procedure

substituting 3-{3-[4-(2-(2,2,2-trifluoroethoxy)phenyl)piperazin-1-yl]propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione and 4-chlorobenzyl chloride gave 1-(4-chlorobenzyl)-3-{3-[4-(2-(2,2,2-trifluoroethoxy)phenyl)piperazin-1-yl]-propyl}-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, m.p. 170°-172° C.; Anal.: Calcd. for C27H30ClF3N4O3.HCl: C, 55.20; H, 5.31; N, 9.53%; Found: C, 55.01; H, 5.24; N, 9.56%;

Sources & evidence

ORD record
ord-da3a528b68f04b0eb2d32f98c17781b4
Source dataset
uspto-grants-1999_01
Patent number
US05859014

Reaction notes

Loading…