HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 8-(2,6-Dichloro-3-nitrobenzyloxy)-2-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Methyl-8-hydroxyquinoline | HCID 13224 | — |
| Reactant | 2,6-Dichloro-3-nitrobenzyl Bromide | HCID 11011535 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-(2,6-Dichloro-3-nitrobenzyloxy)-2-methylquinoline | HCID 10498914 | — |
Reaction Steps
Cs2CO3 (10.8 g, 33.3 mmol) was added at room temperature to 8-hydroxy-2-methylquinoline (5 g, 33.3 mmol) in DMF (65 ml). After 30 min, 2,6-dichloro-3-nitrobenzyl bromide (13 g, 45.6 mmol) was added. After 18 h, H2O was added and the precipitate was filtered off with suction and washed with EA (50 ml), the title compound being obtained as an amorphous substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05859025 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-a8be8013f9e0459f8433499fad2dcbee |
| Source note | uspto-grants-1999_01 |