反应详情

To a mixture of acids containing 370 ml of conc. sulfuric acid and 61.2 ml of 70% nitric acid, 36.6 g of 2,4,5-trifluoro-3-methylbenzoic acid was added portionwise at the inner temperature of 55°-70° C. with stirring, and then stirring was continued for 2 hours at room temperature. The reaction mixture was poured into ice and extracted with isopropyl ether. The extract was washed with brine, and then dried and concentrated to give 30.6 g of yellow crystals.

1. additionTo a mixture of acids
2. additionwas added portionwise at the inner temperature of 55°-70° C.
3. stirringstirring
4. additionThe reaction mixture was poured into ice
5. extractionextracted with isopropyl ether
6. washThe extract was washed with brine
7. customdried
8. concentrationconcentrated