Water → HCID 54179754, compound

Participants

Reaction Steps

To a solution of the ester from Step D (719 mg, 2.23 mmol) in 10 mL of dichloromethane at room temperature was added water (1 mL) and trifluoroacetic acid (1 mL). After 16 hours, the reaction was poured into EtOAc, washed with sat, NaHCO3 soln. and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the aldehyde (0.53 g, 100% yield) as a yellow oil which was sufficiently pure for use in the next step without further purification.

Provenance & Evidence