Sodium Hydroxide → HCID 67577772, compound

HRID 342633Notes

Reaction equation

HRID 342633 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]=2)[C:7]=1[CH3:23].[SH:24][C:25]1[NH:29][C:28]2[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=2[N:26]=1.[OH-].[Na+]>C(O)C.O>[CH3:23][C:7]1[C:8]([CH2:12][S:13][C:14]2[NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]=2)=[N:9][CH:10]=[CH:11][C:6]=1[S:5][CH2:4][CH2:3][CH2:2][S:24][C:25]1[NH:29][C:28]2[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=2[N:26]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 19075193HCID 19075193, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 67577772HCID 67577772, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2-{[[4-(3-Chloropropylthio)-3-methyl-2-pyridinyl]methyl]thio}-1 H-benzimidazole (1 mmol) is stirred at 60° C. for 20 h with 2-mercapto-1 H-benzimidazole (1.05 mmol) and 1N sodium hydroxide solution (3 ml) in 10 ml of ethanol and subsequently diluted with a further 10 ml of water. The mixture is allowed to cool, and the precipitated solid is filtered off, washed with ethanol/water 1/1 and dried in vacuo at 50° C. The title compound is obtained as a gray powder; m.p. 85°-87° C.; yield: 83% of theory.

Workup

  1. temperatureto cool
  2. filtrationthe precipitated solid is filtered off
  3. washwashed with ethanol/water 1/1
  4. customdried in vacuo at 50° C

Sources & evidence

ORD record
ord-09a2fb488e4b4b97b86763391c091a1c
Source dataset
uspto-grants-1999_01
Patent number
US05859030

Reaction notes

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