Water → HCID 10960386, compound

HRID 342653Notes

Reaction equation

HRID 342653 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:14])(=[O:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].[Cl:15][C:16]1[CH:17]=[C:18]([NH:22][C:23](=[S:25])[S-:24])[CH:19]=[CH:20][CH:21]=1.C([NH+](CC)CC)C.O>C(#N)C.CCOCC>[Cl:15][C:16]1[CH:17]=[C:18]([N:22]2[C:3]([C:5]3[CH:10]=[CH:9][C:8]([S:11]([NH2:14])(=[O:13])=[O:12])=[CH:7][CH:6]=3)([OH:4])[CH2:2][S:25][C:23]2=[S:24])[CH:19]=[CH:20][CH:21]=1

Participants

6

Reactant 3

HCID 962WaterHCID 10979641HCID 10979641, compoundHCID 118327234-(2-Bromo-acetyl)-benzenesulfonamide

Product 1

HCID 10960386HCID 10960386, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6342AcetonitrileSolvent

Procedure

5 g of the product of Example 5 and 5.5 g of the product of Example 6 are dissolved in 60 ml of acetonitrile, and the mixture is stirred for 5 h at ambient temperature. It is then poured into 500 ml of water, extracted with dichloromethane, the dichloromethane phase is then washed with water, then dried over magnesium sulphate and evaporated off. The solid obtained is taken up in ether and filtered.

Workup

  1. extractionextracted with dichloromethane
  2. washthe dichloromethane phase is then washed with water
  3. dry with materialdried over magnesium sulphate
  4. customevaporated off
  5. customThe solid obtained
  6. filtrationfiltered

Sources & evidence

ORD record
ord-be9513959557436cabc8dfadda14067b
Source dataset
uspto-grants-1999_01
Patent number
US05859036

Reaction notes

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