HRID34267

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10774141

4-(bromomethyl)-5-methyl-1,3-dioxol-2-one

C5H5BrO3

$结构：CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)[O-])=C(CSc3ncns3)CS[C@H]12)c1cscn1.[Na+]$

HCID88640700

未命名化合物

PRODUCTS

生成物

$结构：CO/N=C(\C(=O)NC1C(=O)N2C(C(=O)OCc3oc(=O)oc3C)=C(CSc3ncns3)CS[C@H]12)c1cscn1$

HCID172930572

未命名化合物

收率 31%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

4-Bromomethyl-5-methyl-1,3-dioxolene-2-one (386 mg) was added to a solution of sodium 7-[(Z)-2-methoxyimino-2-(thiazol-4-yl)acetamido]-3-(1,2,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate (522 mg) in N,N-dimethylformamide (5 ml) at -5° C. and the mixture was stirred at this temperature for 1.3 hr. The reaction mixture was then treated in the same manner as in Example 14, giving the title compound (190 mg). ##STR39##

WORKUP

后处理

additionThe reaction mixture was then treated in the same manner as in Example 14

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e9ce1ee0f8444199b4d7994e2d1adb06
来源数据集: uspto-grants-1988_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04761409
来源说明: uspto-grants-1988_08

反应 SMILES

Br[CH2:2][C:3]1[O:4][C:5](=[O:9])[O:6][C:7]=1[CH3:8].[CH3:10][O:11]/[N:12]=[C:13](/[C:36]1[N:37]=[CH:38][S:39][CH:40]=1)\[C:14]([NH:16][CH:17]1[C:34](=[O:35])[N:19]2[C:20]([C:31]([O-:33])=[O:32])=[C:21]([CH2:24][S:25][C:26]3[S:30][N:29]=[CH:28][N:27]=3)[CH2:22][S:23][C@H:18]12)=[O:15].[Na+]>CN(C)C=O>[CH3:8][C:7]1[O:6][C:5](=[O:9])[O:4][C:3]=1[CH2:2][O:33][C:31]([C:20]1[N:19]2[C:34](=[O:35])[CH:17]([NH:16][C:14](=[O:15])/[C:13](=[N:12]\[O:11][CH3:10])/[C:36]3[N:37]=[CH:38][S:39][CH:40]=3)[C@H:18]2[S:23][CH2:22][C:21]=1[CH2:24][S:25][C:26]1[S:30][N:29]=[CH:28][N:27]=1)=[O:32]