Acetyl chloride → HCID 69710480, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 4-[5-(2-aminopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester (Example 12) (0.220 g, 0.421 mmole) in THF (4 mL) under argon at 0° C. was added diisopropylethylamine (0.22 mL, 1.26 mmole) followed by acetyl chloride (0.036 mL, 0.50 mmole). The reaction was stirred at 20° C. for 1 hour, diluted with water (10 mL) and product extracted with ethyl acetate (2×50 mL). The ethyl acetate extracts were dried over anhydrous sodium sulfate, filtered, concentrated and chromatographed on silica using 5% methanol/methylene chloride to give the product (0.170 g) as an oil.

Provenance & Evidence