反应详情

A solution of 1-(4-cyanobenzyl)-5-(hydroxymethyl)imidazole (1.00 g, 4.70 mmol), in thionyl chloride (5 mL), was stirred at 70° C. for 16 hours. The solvent was evaporated in vacuo and the resulting solid suspended in CH2Cl2, collected by filtration and dried in vacuo. The material was sufficiently pure for use in the next step without further purification.

1. customThe solvent was evaporated in vacuo
2. filtrationcollected by filtration
3. customdried in vacuo
4. customThe material was sufficiently pure for use in the next step without further purification